Which of the following is the reversal agent for Dabigatran?

Which of the following is the reversal agent for Dabigatran?

• A. Andexanet alfa
• B. Idarucizumab
• C. Protamine sulfate
• D. Vitamin K

Answer: (B)

Dabigatran is a direct thrombin inhibitor used for anticoagulation. The reversal agent specifically designed for Dabigatran is idarucizumab. It is a monoclonal antibody fragment that binds to dabigatran with high affinity, effectively neutralizing its anticoagulant effect. This is particularly important in situations of major bleeding or when urgent surgery is needed, as it allows for rapid restoration of normal coagulation function. Idarucizumab works quickly, and its use is indicated in patients who have taken Dabigatran and need immediate reversal of its effects, differentiating it from other reversal agents that address different anticoagulants. Other agents listed, such as andexanet alfa (used for factor Xa inhibitors) and protamine sulfate (used for heparin reversal), do not act on Dabigatran. Vitamin K is primarily used for reversing the effects of vitamin K antagonists like warfarin and is not effective against Dabigatran. Thus, idarucizumab is the appropriate and correct choice for reversing the anticoagulant effects of Dabigatran.

Dabigatran is a direct thrombin inhibitor used for anticoagulation. The reversal agent specifically designed for Dabigatran is idarucizumab. It is a monoclonal antibody fragment that binds to dabigatran with high affinity, effectively neutralizing its anticoagulant effect. This is particularly important in situations of major bleeding or when urgent surgery is needed, as it allows for rapid restoration of normal coagulation function.

Idarucizumab works quickly, and its use is indicated in patients who have taken Dabigatran and need immediate reversal of its effects, differentiating it from other reversal agents that address different anticoagulants. Other agents listed, such as andexanet alfa (used for factor Xa inhibitors) and protamine sulfate (used for heparin reversal), do not act on Dabigatran. Vitamin K is primarily used for reversing the effects of vitamin K antagonists like warfarin and is not effective against Dabigatran. Thus, idarucizumab is the appropriate and correct choice for reversing the anticoagulant effects of Dabigatran.